CMSBAD
CENTER FOR
BIOLOGICAL SYSTEMS MODELING AND
DATA ANALYSIS
Research Center
accredited by CNCSIS
National Council
for Scientific Research in Higher Education
Director: prof dr
George I Mihalas
Strategic
objectives:
- Participation in a FP7 Consortium for
“Virtual Physiological Human”
- Collaboration with similar teams
- Co-operation in scientific projects
Scientific
objectives:
- Elaborate
mathematical models for biological systems relevant to human physiology and
cell biology
- Develop
computer software for simulations based on mathematical models of biological
processes
- Process
experimental data for model validation
- Analyze
medical data and apply information technology in health care
- Conduct
research projects in national and international collaboration
E-mail: mihalas@umft.ro
Structure:
4
Medical Informatics Group
4
Biophysiscs Group
4
Physiology Group
Organized
Events:
Workshop MIE’96:
Modeling and
Simulation of Biological Processes, Copenhagen, August, 1996
National Medical
Informatics Conference MEDINF 2002: Trends in Romanian e-Health, June 13-15, 2002, Timişoara Romania.
STC2006 &
Romedinf - EFMI Special Topic Conferences: Integrating Biomedical Information:
from eCell to ePacient – April 6 – 8, 2006, Timisoara, Romania.
Projects:
Grant MCT
1997/1998 Modelarea matematica si simularea pe calculator a reglajului genetic
cu gene interrelate
Grant VIASAN 312/2004:
BIOVIEW
– program package for biological systems simulation with dedicated interface.
FP6 IST Programme nr. 027370/2005: QREC - European Quality Labeling and Certification of Electronic Health
Record systems (EHRs)
Grant CEEX 11/2005: NANOSIM –
Transport and structure formation at the micro/nanometer length scale in
biomedicine and materials science.
Grant CEEX 2006: MaternQual
– Integrated information system for evaluating the factors associated with risk
prediction and quality in obstetrics.
Publications(selection):
Mihalaş G.I, Niculescu-Duvaz I., Simon Z. – Trigger with positive
control for gene activity regulation. Computer simulation. Studia Biophysica
1985, vol. 107, nr. 3, p 223-229
Mihalaş G I. Computer Simulation
of Membrane Phenomena R. In: Salamon, B. Blum., M. Jorgense (eds), MEDINFO 86,
North Holland, Amsterdam 1986, p.1118
Mihalaş G I – Computers in Biophysical Analysis of Epithelial
Secretory Membranes – in „Progress in Computer-Assisted Function Analysis”,
J.L. Willems, J H van Bemmel, J. Michel, eds, North Holland, Amsterdam, 1988,
p. 149-154
Mihalaş
G I, Kigyosi A, Lungeanu D, Vernic C. Modeling and simulation in molecular
pharmacology. In: Cesnik B, Mc Cray AT, Scherrer J R, (eds). MEDINFO’98 , IOS
Press, Amsterdam, 1998: 372-375
Mihalaş G I. Modelling and simulation in
medicine and life sciences. Medical Informatics, (Taylor &Francis) vol 23, (no. 2), 1998: 93-96
Lungeanu D, Popa C, Hotca S, Macovievici G. Modelling biological
depth perception in inocular vision: the local disparity estimation. Medical Informatics (Taylor&Francis Ltd);
1998, vol. 23, no. 2: 131-14
Mihalaş G I, Simon
Z, Balea G, Popa E. Possible Oscillatory Behaviour in P53-MDM2 Interaction.
Computer Simulation. Journal of Biological Systems, vol. 8, nr. 1, 2000: 21-29
Neagu Monica, Neagu A.
On the Na, K pump in fluctuating membrane potential, European Biophysics
Journal, 30 , 221 (2001).
Neagu A, Neagu Monica, Dér A. Fluctuations and the
Hofmeister effect, Biophysical Journal, 81,
1285 (2001).
Mihalas G I,
Zaharie D, Kigyosi A. Step-wise or Continous Activation in Cell Regulation? A
Comparative Study of p53-mdm2 Interaction by Computer Simulation. In: Fieschi M et al (eds), MEDINFO2004, Amsterdam: IOS Press,1758
Mihalaş Gh. I., Neamţu M., Opriş D., Horhat F.R. A
dynamic p53-Mdm2 Model with Time delay. Chaos,
Solitons & Fractals J., 30, (2006), no. 4, pp. 936-945.